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In structural biology, the three-dimensional structures of biological macromolecules are elucidated to understand their functions. It provides insights into molecular interactions using X-ray crystallography and NMR spectroscopy techniques. A synthetic biology system, on the other hand, is designed to be used for novel purposes. Combining the principles of biology and engineering, it designs and constructs artificial biological components. Together, these disciplines contribute to understanding and manipulating biological systems, fostering advancements in medicine, biotechnology, and beyond.